B., Burlina, A. P., Dixon, M., Duran, M., Goodman, S. I., Koeller, D. M., Muller, E., Naughten, E. R., Neumaier-Probst, E., Okun, J. G., Kyllerman, M., Surtees, R. A., Wilcken, B., Hoffmann, G. F., and Burgard, P. Guideline for the diagnosis and management of glutaryl-CoA dehydrogenase deficiency (glutaric aciduria type I). Nat Med. 1999; Mitwalli, A. H., Al-Wakeel, J. S., Alam, A., Tarif, N., Abu-Aisha, H., Rashed, M., and Al, Nahed N. L-carnitine supplementation in hemodialysis patients. Askarpour M, Hadi A, Symonds ME, et al. Long-term acetyl-L-carnitine treatment in Alzheimer's Disease. J Inherit.Metab Dis 6-15-2010; View abstract. J Inherit.Metab Dis 2007;30(1):5-22. What time of day is best to take L-carnitine? [Updated!] View abstract. Ferrari R, Cucchini F, Dilisa F, and et al. 2006;29(2):100-107. View abstract. High doses of L-carnitine in acute myocardial infarction: metabolic and antiarrhythmic effects. Online ahead of print. View abstract. View abstract. Minerva Anestesiol. Am J Clin Nutr 1980;33(7):1489-1492. View abstract. 2008;46(2):181-190. Endocr J 2018;65(5):521-6. 2014 Jul 21;14:88. Spiekerkoetter, U., Lindner, M., Santer, R., Grotzke, M., Baumgartner, M. R., Boehles, H., Das, A., Haase, C., Hennermann, J. View abstract. A single-center prospective pilot study. Q. View abstract. Pola, P., Tondi, P., Flore, R., Serricchio, M., Dal Lago, A., Amanti, C., Consorti, F., Benedetti, M., and Midiri, H. Effect of l-carnitine on lipid pattern in debilitated patients treated with Intralipid. J Am.Board Fam.Med. View abstract. Int J Vitam Nutr Res 1995;65:211-4. Reuter, S. E. and Evans, A. M. Long-chain acylcarnitine deficiency in patients with chronic fatigue syndrome. Clin Ter. View abstract. Effects of L-carnitine supplementation on lipid profiles in patients with coronary artery disease. Nausea and Vomiting The Linus Pauling Institute notes that common side effects of taking L-carnitine supplements are nausea and vomiting 1. Int.J Cardiol. A. Drug class: Nutraceutical products. View abstract. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Reprod.Biomed.Online. 1988;192(4):155-157. View abstract. Pregnancy-related changes of carnitine and acylcarnitine concentrations of plasma and erythrocytes. View abstract. View abstract. View abstract. Milio, G., Novo, G., Genova, C., Luigi, Almasio P., Novo, S., and Pinto, A. Pharmacological treatment of patients with chronic critical limb ischemia: L-propionyl-carnitine enhances the short-term effects of PGE-1. Three-year survival of patients with heart failure caused by dilated cardiomyopathy and L-carnitine administration. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Sulkers, E. J., Lafeber, H. N., Degenhart, H. J., Przyrembel, H., Schlotzer, E., and Sauer, P. J. Metabolic effects of continuous or acute carnitine administration with special reference to fat oxidation and nitrogen utilization. Yeh, Y. Y., Cooke, R. J., and Zee, P. Impairment of lipid emulsion metabolism associated with carnitine insufficiency in premature infants. Kosolcharoen T, Nappi J, Peduzzi P, and et al. View abstract. 2014 Jul 12;12:65. DiMauro, S. and Hirano, M. Mitochondrial DNA Deletion Syndromes. L-Carnitine is a naturally occurring substance that the body needs for energy. Adding L-carnitine to clomiphene resistant PCOS women improves the quality of ovulation and the pregnancy rate. Zhonghua Nan.Ke.Xue. Int J Curr Res Acad Rev 2015;3:469-76. HIV.Med. Benefits of L-carnitine. View abstract. Crill, C. M., Christensen, M. L., Storm, M. C., and Helms, R. A. View abstract. 2010;66(2):127-136. Pediatr.Res. Pivalate-generating prodrugs and carnitine homeostasis in man. Effect of acetylcarnitine treatment in oligoasthenospermic patients. View abstract. 2010;34(3):295-299. View abstract. View abstract. Mezzina C, De Grandis D, Calvani M, et al. Neurochem.Res. Acta Paediatr Hung 1986;27:253-8. Garzya G, Corallo D, Fiore A, et al. Effect de la L-carnitine chez les patients en hemodialyse chronique traite e par erythropoietine recombinante [abstract]. Mol.Psychiatry 2012;17(3):290-314. Biolo, G., Stulle, M., Bianco, F., Mengozzi, G., Barazzoni, R., Vasile, A., Panzetta, G., and Guarnieri, G. Insulin action on glucose and protein metabolism during L-carnitine supplementation in maintenance haemodialysis patients. 2010;48(5):503-510. Am.J Hypertens. Cochrane.Database.Syst.Rev. Heart complications (such as irregular heartbeat and heart failure). Blood 1998;91:3817-24. Carnitine is also synthesized endogenously in the liver . Life Sci 1996;59:1579-99. Amino.Acids 2009;36(2):365-372. Huang, Y., Huang, L. C., and Zhan, F. Clinical analysis of therapeutic effect of levocarnitine on dialysis patients. Gheissari A, Aslani N, Eshraghi A, et al. But athletes use acetyl-l-carnitine as a handy supplement to improve focus, mental energy, and even sleep. Pistone G, Marino A, Leotta C, et al. 2007;22(6):330-337. Chen, X. F., Li, Z., Ping, P., Dai, J. C., Zhang, F. B., and Shang, X. J. Haghighatdoost F, Jabbari M, Hariri M. The effect of L-carnitine on inflammatory mediators: a systematic review and meta-analysis of randomized clinical trials. Sci Rep. 2016;6:19188. [Ref], Very common (10% or more): Anemia (12%)[Ref], Common (1% to 10%): Kidney failure (chronic hemodialysis patients)[Ref], Common (1% to 10%): Parathyroid disorder[Ref], Very common (10% or more): Pharyngitis (27%), cough increase (18%), dyspnea (11%), rhinitis (11%), Common (1% to 10%): Bronchitis, sinusitis[Ref], Common (1% to 10%): Amblyopia, eye disorder[Ref], Common (1% to 10%): Urinary tract infection[Ref], Very common (10% or more): Hypertension (21%), hypotension (19%), Common (1% to 10%): Atrial fibrillation, arrhythmia, cardiovascular disorder, electrocardiogram abnormal, palpitations, tachycardia, vascular disorder[Ref], Common (1% to 10%): Allergic reaction[Ref], Common (1% to 10%): Depression, anxiety, drug dependence, insomnia[Ref], Very common (10% or more): Infection (24%)[Ref]. A. J Clin Lipidology 2012;6:150-158. 2009;41(11):840-845. J Gerontol.A Biol.Sci Med.Sci 2008;63(10):1027-1033. View abstract. Passeri, M., Iannuccelli, M., Ciotti, G., Bonati, P. A., Nolfe, G., and Cucinotta, D. Mental impairment in aging: selection of patients, methods of evaluation and therapeutic possibilities of acetyl-L-carnitine. Brain Dev. View abstract. 2009;61(4):215-217. Epilepsia 1993;34:184-7. 2010;16(6):504-509. Diarrhea Exp Clin Endocrinol Diabetes. "So there's a link . Campos Y, Arenas J. L-carnitine is also linked to improvements in patients with severe heart disorders, such as coronary heart disease and chronic heart failure (40, 41). Pourmand G, Movahedin M, Dehghani S, Mehrsai A, Ahmadi A, Pourhosein M, Hoseini M, Ziloochi M, Heidari F, Beladi L, Noori M. Does L-carnitine therapy add any extra benefit to standard inguinal varicocelectomy in terms of deoxyribonucleic acid damage or sperm quality factor indices: a randomized study. Block, K. I., Koch, A. C., Mead, M. N., Tothy, P. K., Newman, R. A., and Gyllenhaal, C. Impact of antioxidant supplementation on chemotherapeutic toxicity: a systematic review of the evidence from randomized controlled trials. Rajasekar, P., Palanisamy, N., and Anuradha, C. V. Increase in nitric oxide and reductions in blood pressure, protein kinase C beta II and oxidative stress by L-carnitine: a study in the fructose-fed hypertensive rat. Dig.Dis Sci 2006;51(12):2242-2247. View abstract. Eur J Appl Physiol Occup Physiol 1990;61:486-90. Sun, Z. J., Yang, C. B., Wang, H., and Li, Y. L-Carnitine Benefits Endurance, Fat Burning and Brain Function 2014 May;29(5):997-1004. Wang DD, Wang TY, Yang Y, He SM, Wang YM. Naito J, Ohashi H, Ohno M, et al. L-carnitine might increase the effects of acenocoumarol and increase the chance of bruising and bleeding. How Much Caffeine Is Okay? Zhou, X., Liu, F., and Zhai, S. Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for male infertility: a systematic review. Am J Clin Nutr 1990;52(5):889-894. Eur Heart J 1994;15:1267-73. Carnitine produces energy in the cells by transporting fatty acids into the mitochondria where they are oxidized into . Spiering, B. Cell Biol.Int. View abstract. Karl M, Rubenstein M, Rudnick C, Brejda J. As with any supplement, you should speak with your doctor before taking L-carnitine. Mantovani G, Maccio A, Madeddu C, et al. A placebo-controlled double-blind randomized trial of the use of combined l-carnitine and l-acetyl-carnitine treatment in men with asthenozoospermia. O'Brien, D., Chunduri, P., Iyer, A., and Brown, L. L-carnitine attenuates cardiac remodelling rather than vascular remodelling in deoxycorticosterone acetate-salt hypertensive rats. View abstract. View abstract. Use of a long-chain triglyceride-restricted/medium-chain triglyceride-supplemented diet in a case of malonyl-CoA decarboxylase deficiency with cardiomyopathy. Eur.Urol. View abstract. 2017;3:CD009374. 2005-2023 Healthline Media a Red Ventures Company. (Pakistan) 2006;6(5):800-805. View abstract. Jirillo, E., Altamura, M., Munno, I., Pellegrino, N. M., Sabato, R., Di Fabio, S., and De Simone, C. Effects of acetyl-L-carnitine oral administration on lymphocyte antibacterial activity and TNF-alpha levels in patients with active pulmonary tuberculosis. J Inherit.Metab Dis 2009;32(4):488-497. Lenzi A, Sgro P, Salacone P, et al. Hepatology 1997;25:148-53. J Nephrol. Barditch-Crovo P, Toole J, Hendrix CW, et al. Janiri, L., Martinotti, G., Tonioni, F., Ghelardini, C., Nicolai, R., Galeotti, N., Mosconi, L., Calvani, M., Bartolini, A., and Iannoni, E. Acetyl-L-carnitine in the management of pain during methadone withdrawal syndrome. View abstract. Int.J Sport Nutr.Exerc.Metab 2008;18(1):19-36. View abstract. Lee, P. J., Harrison, E. L., Jones, M. G., Jones, S., Leonard, J. V., and Chalmers, R. A. L-carnitine and exercise tolerance in medium-chain acyl-coenzyme A dehydrogenase (MCAD) deficiency: a pilot study. Zhongguo Wei Zhong.Bing.Ji.Jiu.Yi Xue 2011;23(12):739-742. Greco, A. V., Mingrone, G., Bianchi, M., and Ghirlanda, G. Effect of propionyl-L-carnitine in the treatment of diabetic angiopathy: controlled double blind trial versus placebo. Biol.Neonate 1987;51(4):185-193. View abstract. Cardiovasc.Drugs Ther 2009;23(4):301-306. 2011;37(10):1716-1717. Guideri, F., Acampa, M., Hayek, Y., and Zappella, M. Effects of acetyl-L-carnitine on cardiac dysautonomia in Rett syndrome: prevention of sudden death? View abstract. View abstract. Khajeh B, Dashti-Khavidaki S, Nasiri-Toosi M, Mohammadi K, Jafari A. Beneficial effects of L-carnitine in the reduction of the necrotic area in acute myocardial infarction. Ricci, A., Caiati, C., Galantino, A., Scrutinio, D., Valentini, G., Chiddo, A., and Rizzon, P. [Acute effects of propionyl-L-carnitine on anomalies of parietal kinetics of the left ventricle induced by atrial pacing in patients with ischemic heart disease. Circulation 5-1-1996;93(9):1685-1689. Insomnia; Energy drinks can cause insomnia, especially when it . J Ren Nutr. Ageing Res.Rev. View abstract. Andrologia 1994;26(3):155-159. BMC Comp Altern Med 2002;2:5. View abstract. Sabba, C., Berardi, E., Antonica, G., Ferraioli, G., Buonamico, P., Godi, L., Brevetti, G., and Albano, O. View abstract. Anemia and carnitine supplementation in hemodialyzed patients. Carnosine supplements are available as powders and capsules. Roy, M. J., Dionne, S., Marx, G., Qureshi, I., Sarma, D., Levy, E., and Seidman, E. G. In vitro studies on the inhibition of colon cancer by butyrate and carnitine. Bipolar.Disord. Derosa, G., Maffioli, P., Salvadeo, S. A., Ferrari, I., Gravina, A., Mereu, R., D'Angelo, A., Palumbo, I., Randazzo, S., and Cicero, A. F. Sibutramine and L-carnitine compared to sibutramine alone on insulin resistance in diabetic patients. View abstract. De Pasquale, B., Righetti, G., and Menotti, A. Acta Urol Ital 1996;10(3):185-187. Schweiz.Med Wochenschr 9-12-1992;122(37):1352-1355. Graziano F, Bisonni R, Catalano V, et al. Several conditions can cause bradycardia, including several potentially serious conditions, such as myocarditis, sleep apnea, lupus or certain medications. Your metabolism determines how many calories you burn each day. Herrmann, W. M., Dietrich, B., and Hiersemenzel, R. Pharmaco-electroencephalographic and clinical effects of the cholinergic substance--acetyl-L-carnitine--in patients with organic brain syndrome. Note: This document contains side effect information about levocarnitine. Zanardi, R. and Smeraldi, E. A double-blind, randomised, controlled clinical trial of acetyl-L-carnitine vs. amisulpride in the treatment of dysthymia. Interventions for treating leg ulcers in people with sickle cell disease. View abstract. Acta Diabetol. Basic Clin Pharmacol Toxicol. Cavallini G, Biagiotti G, Koverech A, Vitali G. Oral propionyl-l-carnitine and intraplaque verapamil in the therapy of advanced and resistant Peyronie's disease. Vitamins & Supplements That Help or Cause Insomnia - ConsumerLab.com Clin Neuropharmacol. View abstract. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Exploratory open label, randomized study of acetyl- and propionylcarnitine in chronic fatigue syndrome. Clinical and biochemical effects. Carnitor (levocarnitine)." Reprod.Biomed.Online. View abstract. Drugs 1999;58:479-87. Very common (10% or more): Diarrhea (35%), abdominal pain (21%), vomiting (21%), nausea (12%), Common (1% to 10%): Constipation, dyspepsia, gastrointestinal disorder, melena, Very rare (less than 0.01%): Abdominal cramps[Ref], Very common (10% or more): Headache (37%), dizziness (18%), paresthesia (12%), Common (1% to 10%): Hypertonia, vertigo, taste perversion, Frequency not reported: Seizures (with or without pre-existing seizure activity), increase in seizure frequency and/or severity[Ref], There are reports from clinical trials of significant hypertriglyceridemia associated with high doses of levocarnitine (the active ingredient contained in L-Carnitine) (3 g/day) given to uremic dialysis patients. Int.Clin Psychopharmacol. View abstract. Location. Digiesi, V., Palchetti, R., and Cantini, F. [The benefits of L-carnitine therapy in essential arterial hypertension with diabetes mellitus type II]. View abstract. 2011;46(6):750-759. Coulter DL. A Meta-Analysis of the Efficacy of L-Carnitine/L-Acetyl-Carnitine or N-Acetyl-Cysteine in Men With Idiopathic Asthenozoospermia. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Am.J Med.Genet.A 4-1-2008;146(7):803-812. Clin Genet. Cancer Biol.Ther 7-15-2011;12(2):125-130. Double-blind parallel design pilot study of acetyl levocarnitine in patients with Alzheimer's Disease. Anti-human immunodeficiency virus (HIV) activitiy, safety, and pharmacokinetics of adefovir dipivoxyl (9-[2-(bis-pivaloyloxymethyl)-phosphonylmethoxyethyl]adenine) in HIV-infected patients. Gynecol.Oncol 2012;124(3):417-425. 2009;48(5):587-596. View abstract. Ma, S. J., Cai, W. W., and Sheng, J. Zhang X, Cui Y, Dong L, Sun M, Zhang Y. These symptoms are not considered to be severe side effects. View abstract. Fernandez, C. and Proto, C. [L-carnitine in the treatment of chronic myocardial ischemia. 2012;7(11):1836-1842. It can cause nausea, vomiting, stomach pain, weakness, and chest pain (angina). Rausch CR, Paul S, Marx KR, et al. Fan, J. P., Kim, H. S., and Han, G. D. Induction of apoptosis by L-carnitine through regulation of two main pathways in Hepa1c1c 7 cells. Cochrane.Database.Syst.Rev. The effects of anti-anxiety and depression therapy on life quality of patient with coronary heart disease. Morano, S., Mandosi, E., Fallarino, M., Gatti, A., Tiberti, C., Sensi, M., Gandini, L., Buchetti, B., Lenti, L., Jannini, E. A., and Lenzi, A. Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: a double-blind, placebo-controlled study. View abstract. Med.Clin (Barc.) This was not something I was expecting. Ann N Y Acad Sci 2004;1033:158-67. Jacoba KG, Abarquez RF, Topacio GO, and et al. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. 2007;86(1):31-34. Oncologist. Malvagia, S., Papi, L., Morrone, A., Donati, M. A., Ciani, F., Pasquini, E., la, Marca G., Scholte, H. R., Genuardi, M., and Zammarchi, E. Fatal malonyl CoA decarboxylase deficiency due to maternal uniparental isodisomy of the telomeric end of chromosome 16. View abstract. Rossini, M., Di, Munno O., Valentini, G., Bianchi, G., Biasi, G., Cacace, E., Malesci, D., La, Montagna G., Viapiana, O., and Adami, S. Double-blind, multicenter trial comparing acetyl l-carnitine with placebo in the treatment of fibromyalgia patients. Liu, S., Wu, H. J., Zhang, Z. Q., Chen, Q., Liu, B., Wu, J. P., and Zhu, L. L-carnitine ameliorates cancer cachexia in mice by regulating the expression and activity of carnitine palmityl transferase. Mantovani, G., Maccio, A., Madeddu, C., Gramignano, G., Serpe, R., Massa, E., Dessi, M., Tanca, F. M., Sanna, E., Deiana, L., Panzone, F., Contu, P., and Floris, C. Randomized phase III clinical trial of five different arms of treatment for patients with cancer cachexia: interim results. [Use of L-carnitine before percutaneous epididymal sperm aspiration-intracytoplasmic sperm injection for obstructive azoospermia]. Inflammation contributes to many medical conditions, including . 2010;38:152-5. View abstract. 2017;25(1):13-4. 2003;79(2):292-300. Evaluation of the efficacy of propionyl-L-carnitine versus pulsed muscular compressions in diabetic and non-diabetic patients affected by obliterating arteriopathy Leriche stage II. View abstract. Wang Y, Xu Y, Zou R, et al. Ghidini O, Azzurro M, Vita G, Sartori G. Evaluation of the therapeutic efficacy of L-carnitine in congestive heart failure. Srivastava DK, Kumar S Misra AP. Oral L-carnitine supplementation in low-birth-weight newborns: a study on neonates requiring combined parenteral and enteral nutrition. Brain Dev. Carnitine, derived from an amino acid, is the generic term for several compounds, including L-carnitine, acetyl-L-carnitine, and propionyl-L-carnitine [ 1 ]. Weinhandl, E. D., Rao, M., Gilbertson, D. T., Collins, A. J., and Pereira, B. J. View abstract. Segura-Bruna, N., Rodriguez-Campello, A., Puente, V., and Roquer, J. Valproate-induced hyperammonemic encephalopathy. Brand names: Carnitor, L-Carnitine Metabolism 2008;57(4):549-554. Calabrese, V., Cornelius, C., Mancuso, C., Lentile, R., Stella, A. M., and Butterfield, D. A. Redox homeostasis and cellular stress response in aging and neurodegeneration. Ismail AM, Hamed AH, Saso S, Thabet HH. 1989;26(2):111-129. Propionyl carnitine in stable effort angina. Casciani, C. U., Caruso, U., Cravotto, E., Corsi, M., Pola, P., Savi, L., and Grilli, M. Effect of L-carnitine on lipid pattern in haemodialysis. Dietary supplements for erectile dysfunction: A natural treatment for Pignatelli, P., Tellan, G., Marandola, M., Carnevale, R., Loffredo, L., Schillizzi, M., Proietti, M., Violi, F., Chirletti, P., and Delogu, G. Effect of L-carnitine on oxidative stress and platelet activation after major surgery. Samimi M, Jamilian M, Ebrahimi FA, Rahimi M, Tajbakhsh B, Asemi Z. Cureus. Other drugs may interact with levocarnitine, including prescription and over-the-counter medicines, vitamins, and herbal products. Dig.Dis Sci 2006;51(3):488-494. View abstract. Ren Fail. Ishikura H, Matsuo N, Matsubara M, et al. Fulgente T, Onofrj M Del Re ML et al. J.Japanese Society Nutrition Food Sci 2007;60(5):257-264. 2012 Winter;24(1):E18-9. This includes older adults and people who rarely or never eat meat and fish. Pastoris, O., Dossena, M., Foppa, P., Catapano, M., Arbustini, E., Bellini, O., Dal Bello, B., Minzioni, G., Ceriana, P., and Barzaghi, N. Effect of L-carnitine on myocardial metabolism: results of a balanced, placebo-controlled, double-blind study in patients undergoing open heart surgery. Analysis of the full dataset has . Rett syndrome: randomized controlled trial of L-carnitine. Arch.Pharm Res 2012;35(11):1945-1952. Tempesta E, Casella L, Pirrongelli C, et al. Does carnitine cause insomnia? We comply with the HONcode standard for trustworthy health information. AIDS Res.Hum.Retroviruses 2010;26(11):1207-1214. Skip the missed dose if it is almost time for your next scheduled dose. Indian J Exp.Biol. Neuromuscul.Disord. Protective role of carnitine in breast cancer via decreasing arginase activity and increasing nitric oxide. View abstract. [The anti-arrhythmic effect of L-carnitine in subjects with ischemic cardiopathy]. View abstract. 1986;13(6):268-276. J.Med.Sci. It can cause side effects such as stomach upset, heartburn, diarrhea, and seizures. Cardiology 2010;116:178-82. Potential role of levocarnitine supplementation for the treatment of chemotherapy-induced fatigue in non-anaemic cancer patients. Acta Cardiol. Effect of L-carnitine supplementation on acute valproate intoxication. Van Oudheusden, L. J. and Scholte, H. R. Efficacy of carnitine in the treatment of children with attention-deficit hyperactivity disorder. View abstract. Here are several other types of carnitine: For most people, acetyl-L-carnitine and L-carnitine seem to be the most effective for general use. In addition to the L-carnitine produced in your body, you can also obtain small amounts by eating animal products like meat or fish (5). Current Therapeutic Research 1986;39(3):429-435. Levocarnitine administration in elderly subjects with rapid muscle fatigue: effect on body composition, lipid profile and fatigue. Gentile V, Vicini P, Prigiotti G, et al. Protective effect of acetyl-L-carnitine on the apoptotic pathway of peripheral . Warfarin is used to slow blood clotting. Sloan, R. S., Kastan, B., Rice, S. I., Sallee, C. W., Yuenger, N. J., Smith, B., Ward, R. A., Brier, M. E., and Golper, T. A. View abstract. Disclaimer: Go To See My Account. View abstract. Bloomer, R. J., Farney, T. M., Trepanowski, J. F., McCarthy, C. G., Canale, R. E., and Schilling, B. K. Comparison of pre-workout nitric oxide stimulating dietary supplements on skeletal muscle oxygen saturation, blood nitrate/nitrite, lipid peroxidation, and upper body exercise performance in resistance trained men. Nephrologie 1998;19:171. For these reasons, L-carnitine supplements are only necessary in special cases, such as disease treatment. Cruciani RA, Zhang JJ, Manola J, Cella D, Ansari B, Fisch MJ. View abstract. Are There Side Effects to L-Carnitine Supplementation? View abstract. Rondanelli M, Opizzi A, Perna S, Faliva M, Solerte SB, Fioravanti M, Klersy C, Edda C, Maddalena P, Luciano S, Paola C, Emanuela C, Claudia S, Donini LM. View abstract. Speak with a healthcare provider to find out what dose might be best for a specific condition. The effect of L-carnitine on mortality rate in septic patients: a systematic review and meta-analysis on randomized clinical trials. View abstract. 1987;24(4):231-234. 2010;20(11):693-700. December 1999. Zhonghua Nei Ke.Za Zhi. Effect of acute administration of L-acetyl carnitine on cerebral blood flow in patients with chronic cerebral infarct. A controlled randomized trial of the use of combined L-carnitine and acetyl-L-carnitine treatment in men with oligoasthenozoospermia. Freeman JM, Vining EPG, Cost S, Singhi P. Does carnitine administration improve the symptoms attributed to anticonvulsant medications? 2020;151:104554. Nephron 55 (1990): 28-32.